Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer
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منابع مشابه
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer.
Two theories of how energy metabolism should be associated with longevity, both mediated via free-radical production, make completely contrary predictions. The 'rate of living-free-radical theory' (Pearl, 1928; Harman, 1956; Sohal, 2002) suggests a negative association, the 'uncoupling to survive' hypothesis (Brand, 2000) suggests the correlation should be positive. Existing empirical data on t...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2004
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9728.2004.00097.x